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Toxic: a chemical that has a median lethal concentration (LC 50) in air of more than 200 parts per million (ppm) but not more than 2,000 parts per million by volume of gas or vapor, or more than 2 milligrams per liter but not more than 20 milligrams per liter of mist, fume or dust, when administered by continuous inhalation for 1 hour (or less if death occurs within 1 hour) to albino rats ...
Carbon dioxide is a gaseous product of the body's metabolism and is normally expelled through the lungs. Carbon dioxide may accumulate in any condition that causes hypoventilation , a reduction of alveolar ventilation (the clearance of air from the small sacs of the lung where gas exchange takes place) as well as resulting from inhalation of CO 2 .
The term immediately dangerous to life or health (IDLH) is defined by the US National Institute for Occupational Safety and Health (NIOSH) as exposure to airborne contaminants that is "likely to cause death or immediate or delayed permanent adverse health effects or prevent escape from such an environment." Examples include smoke or other ...
In humans, this carbon dioxide is carried through the venous system and is breathed out through the lungs, resulting in lower concentrations in the arteries. The carbon dioxide content of the blood is often given as the partial pressure, which is the pressure which carbon dioxide would have had if it alone occupied the volume. [73]
Acute respiratory acidosis occurs when an abrupt failure of ventilation occurs. This failure in ventilation may be caused by depression of the central respiratory center by cerebral disease or drugs, inability to ventilate adequately due to neuromuscular disease (e.g., myasthenia gravis, amyotrophic lateral sclerosis, Guillain–Barré syndrome, muscular dystrophy), or airway obstruction ...
Humans are the main indoor source of carbon dioxide (CO 2) in most buildings. Indoor CO 2 levels are an indicator of the adequacy of outdoor air ventilation relative to indoor occupant density and metabolic activity. Indoor CO 2 levels above 500 ppm can lead to higher blood pressure and heart rate, and increased peripheral blood circulation. [85]
The AEGL values describe the expected effects of inhalation exposure to certain compounds (airborne concentrations in ppm or mg/m 3). Each AEGL is determined by different levels of a compound's toxicological effects, based on the 4 Ds: detection, discomfort, disability and death. There are three levels of AEGL-values: AEGL-1, AEGL-2 and AEGL-3. [2]
The TLV is an estimate based on the known toxicity in humans or animals of a given chemical substance, and the reliability and accuracy of the latest sampling and analytical methods. TLVs do not take into account financial or technical feasibility for application in the workplace, instead solely focusing on health based recommendations to ...