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  2. Baroreflex - Wikipedia

    en.wikipedia.org/wiki/Baroreflex

    The baroreflex or baroreceptor reflex is one of the body's homeostatic mechanisms that helps to maintain blood pressure at nearly constant levels. The baroreflex provides a rapid negative feedback loop in which an elevated blood pressure causes the heart rate to decrease. Decreased blood pressure decreases baroreflex activation and causes heart ...

  3. Baroreflex activation therapy - Wikipedia

    en.wikipedia.org/wiki/Baroreflex_activation_therapy

    Baroreflex activation therapy is an approach to treating high blood pressure and the symptoms of heart failure. It uses an implanted device to electrically stimulate baroreceptors in the carotid sinus region. This elicits a reflex response through the sympathetic and vagal nervous systems that reduces blood pressure.

  4. Aldose reductase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Aldose_reductase_inhibitor

    Aldose reductase activity increases as the glucose concentration rises in diabetes in those tissues that are not insulin sensitive, which include the lenses, peripheral nerves, and glomerulus. Sorbitol does not diffuse through cell membranes easily and therefore accumulates, causing osmotic damage which leads to retinopathy and neuropathy.

  5. Generic Product Identifier - Wikipedia

    en.wikipedia.org/wiki/Generic_Product_Identifier

    The Generic Product Identifier (GPI) is a 14-character hierarchical classification system created by Wolters Kluwer's Medi-Span that identifies drugs from their primary therapeutic use down to the unique interchangeable product regardless of manufacturer or package size. The code consists of seven subsets, each providing increasingly more ...

  6. Baroreceptor - Wikipedia

    en.wikipedia.org/wiki/Baroreceptor

    The baroreceptors can identify the changes in both the average blood pressure or the rate of change in pressure with each arterial pulse. Action potentials triggered in the baroreceptor ending are then directly conducted to the brainstem where central terminations (synapses) transmit this information to neurons within the solitary nucleus [ 6 ...

  7. Canagliflozin - Wikipedia

    en.wikipedia.org/wiki/Canagliflozin

    Canagliflozin is indicated to be used with diet and exercise to lower blood sugar in adults with type 2 diabetes; to reduce the risk of major heart-related events such as heart attack, stroke, or death in people with type 2 diabetes who have known heart disease; and to reduce the risk of end-stage kidney disease, worsening of kidney function, heart-related death, and being hospitalized for ...