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Clonus is a set of involuntary and rhythmic muscular contractions and relaxations. Clonus is a sign of certain neurological conditions, particularly associated with upper motor neuron lesions involving descending motor pathways, and in many cases is accompanied by spasticity (another form of hyperexcitability). [ 1 ]
Hyperreflexia is overactive or overresponsive bodily reflexes. Examples of this include twitching and spastic tendencies, which indicate disease of the upper motor neurons and the lessening or loss of control ordinarily exerted by higher brain centers of lower neural pathways. [citation needed] Spinal cord injury is the most common cause of ...
Clonus seen in a person with serotonin syndrome. Symptom onset is usually relatively rapid, and SS encompasses a wide range of clinical findings. Mild symptoms may consist of increased heart rate, shivering, sweating, dilated pupils, myoclonus (intermittent jerking or twitching), as well as hyperreflexia (overresponsive reflexes). [6]
Any spinal cord lesions, be it traumatic, neoplastic, pyogenic, vascular above the level of S1 can cause clonus. This is because of the spasticity caused by the UMN type of injury causing hyperreflexia and clonus. Some other causes of clonus are Meningitis; Tetanus; CJD; Cerebral palsy; Multiple sclerosis; Syringomyelia; Pre-eclampsia
exaggerated deep tendon reflexes including spasticity, and clonus (a series of involuntary rapid muscle contractions) Such signs are collectively termed the "upper motor neuron syndrome". Affected muscles typically show multiple signs, with severity depending on the degree of damage and other factors that influence motor control. In ...
The presence of the Babinski sign is an abnormal response in adulthood. Normally, during the plantar reflex, it causes plantar flexion and the adduction of the toes. In Babinski's sign, there is dorsiflexion of the big toe and abduction of the other toes. Physiologically, it is normally present in infants from birth to 12 months.
Clonus results due to an increased motor neuron excitation (decreased action potential threshold) and is common in muscles with long conduction delays, such as the long reflex tracts found in distal muscle groups. [7] Clonus is commonly seen in the ankle but may exist in other distal structures as well, such as the knee or spine. [8]
Symptoms associated with central nervous systems disorders are classified into positive and negative categories. Positive symptoms include those that increase muscle activity through hyper-excitability of the stretch reflex (i.e., rigidity and spasticity) where negative symptoms include those of insufficient muscle activity (i.e. weakness) and reduced motor function. [5]