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The mammalian SWI/SNF (mSWI/SNF) complex functions as a tumor suppressor in many human malignant cancers. [13] Early studies identified that SWI/SNF subunits were frequently absent in cancer cell lines. [14] SWI/SNF was first identified in 1998 as a tumor suppressor in rhabdoid tumors, a rare pediatric malignant cancer. [15]
Since the original observation of SMARCB1 mutations in rhabdoid tumors, several more subunits of the human SWI/SNF chromatin remodeling complex have been found mutated in a wide range of neoplasms. [26] The SWI/SNF ATPase BRG1 (or SMARCA4) is the most frequently mutated chromatin remodeling ATPase in cancer. [27]
57376 Ensembl ENSG00000073584 ENSMUSG00000037935 UniProt Q969G3 O54941 RefSeq (mRNA) NM_003079 NM_020618 RefSeq (protein) NP_003070 NP_003070.3 NP_065643 Location (UCSC) Chr 17: 40.62 – 40.65 Mb Chr 11: 99.1 – 99.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in ...
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein in humans that is encoded by the SMARCD2 gene. [5] [6] [7]The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin ...
54380 Ensembl ENSG00000138375 ENSMUSG00000039354 UniProt Q9NZC9 Q8BJL0 RefSeq (mRNA) NM_001127207 NM_014140 NM_018817 RefSeq (protein) NP_001120679 NP_054859 NP_061287 Location (UCSC) Chr 2: 216.41 – 216.48 Mb Chr 1: 72.62 – 72.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 is ...
There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD. [2] The RSC complex is a 15-subunit chromatin remodeling complex initially found in Saccharomyces cerevisiae, and is homologous to the SWI/SNF complex found in humans. [1] The RSC complex has ATPase activity in the presence of DNA. [1]
Gene encoding for ARID1A is the most frequently mutated SWI/SNF subunit across cancers. [9] This gene has been commonly found mutated in different cancers leading to loss of function, including gastric cancers, [10] colon cancer, [11] ovarian clear cell carcinoma, [12] liver cancer, [13] lymphoma [14] and pancreatic cancer. [15]
Protein sequence databases Human Proteinpedia: Institute of Bioinformatics (IOB), Bangalore and Johns Hopkins University, The human Proteinpedia is based on HPRD (Human protein reference database)which is a repository hosting over 30,000 human proteins. However it is unclear how many of these are unique proteins Human Protein Atlas: The Swedish ...