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There are a number of physicochemical and biological properties that determine whether a drug is suitable for being delivered topically through a gel dosage form. Physicochemical properties: The drug must: Have a molecular weight smaller than 500 daltons. [1] [2] Be adequately lipophilic. [1] [2] Have a pH value greater than 5 and smaller than ...
Lethality of cyclopentolate has been studied in rodents. The LD50 (the dose at which 50% of animals die from the drug) is approximately 4000 mg/kg in rats and 960 mg/kg in mice. Readily recognizable symptoms of overdose include tachycardia, dizziness, dry mouth, behavioral disturbances, uncoordination, and drowsiness.
TD gel: 0.5–5 mg/day Various: Estrogen: SC implant: 50–200 mg every 6–24 mos Estradiol valerate: Progynova: Estrogen: Oral: 2–10 mg/day Progynova: Estrogen: Sublingual: 1–8 mg/day Delestrogen [c] Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol cypionate: Depo-Estradiol: Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg ...
Cyclopentene is a chemical compound with the formula (CH 2) 3 (CH) 2. It is a colorless liquid with a petrol-like odor. It has few applications, and thus is mainly used as a minor component of gasoline, present in concentrations of less than 1%. [1] [2] It is one of the principal cycloalkenes.
Octenidine dihydrochloride is active against Gram-positive and Gram-negative bacteria. [5]In vitro suspension tests with 5 minute exposure time have shown that octenidine requires lower effective concentrations than chlorhexidine to kill common bacteria like Staphylococcus aureus, Escherichia coli, Proteus mirabilis and the yeast Candida albicans.
TCEP is available from various chemical suppliers as the hydrochloride salt. When dissolved in water, TCEP-HCl is acidic. A reported preparation is a 0.5 M TCEP-HCl aqueous stock solution that is pH adjusted to near-neutral pH and stored frozen at -20˚C. [12] TCEP is reportedly less stable in phosphate buffers. [12]
Cyclopentobarbital, a drug made from cyclopentanone. Cyclopentanone is also used to make cyclopentamine, the pesticide pencycuron, and pentethylcyclanone. [5] It is also used as a precursor to cubane-1,4-dicarboxylate, which is used to synthesize other substituted cubanes, such as the high explosives heptanitrocubane and octanitrocubane. [6]
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).