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Intrinsic factor is required for the absorption of vitamin B 12 in the diet. A long-term deficiency in vitamin B 12 can lead to megaloblastic anemia, characterized by large fragile red blood cells. Pernicious anaemia results from autoimmune destruction of gastric parietal cells, precluding the synthesis of intrinsic factor and, by extension ...
Intrinsic factor (IF), cobalamin binding intrinsic factor, [5] also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorption of vitamin B 12 later on in the distal ileum of the small intestine. [6]
The same cells in the stomach that produce gastric hydrochloric acid, the parietal cells, also produce a molecule called the intrinsic factor (IF), which binds the B 12 after its release from haptocorrin by digestion, and without which only 1% of vitamin B 12 is absorbed. Intrinsic factor (IF) is a glycoprotein, with a molecular weight of 45 kDa.
Parietal cells produce hydrochloric acid (the effect of which Haptocorrin protects vitamin B 12 from), and also intrinsic factor (IF). Intrinsic factor also has a high binding affinity for vitamin B 12, but because that position is already filled by Haptocorrin, free intrinsic factor, and "Haptocorrin-vitamin B 12" complex, empty from the ...
Lack of intrinsic factor: intrinsic factor is a protein produced by parietal cells in the stomach, and needed in the ileum for the absorption of vitamin B 12. Lack of intrinsic factor is most commonly due to an autoimmune attack on the cells that create it in the stomach, and this condition takes the name "pernicious anemia".
Intrinsic factor, a glycoprotein produced by the parietal cells of the stomach, which is necessary for the absorption of vitamin B 12 Topics referred to by the same term This disambiguation page lists articles associated with the title Castle factors .
The human eye is a sensory organ in the visual system that reacts to visible light allowing eyesight. Other functions include maintaining the circadian rhythm, and keeping balance. Arizona Eye Model. "A" is accommodation in diopters. The eye can be considered as a living optical device.
The parietal eye (very small grey oval between the regular eyes) of a juvenile bullfrog (Lithobates catesbeianus) Adult green anole (Anolis carolinensis) clearly showing the parietal eye (small grey/clear oval) at the top of its head Parietal eye of the Merrem's Madagascar swift (Oplurus cyclurus) is surrounded by a black-and-white spot on the skin, giving it the "three-eyed" appearance