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CA-125 levels can be normal even if you have cancer (false negative), or they can be elevated when you don’t have cancer (false positive). For this reason, a CA-125 test isn’t an effective screening for ovarian cancer.
A CA 125 test measures the amount of the protein CA 125 (cancer antigen 125) in the blood. This test may be used to monitor certain cancers during and after treatment. In some situations, the test may be used to look for early signs of ovarian cancer in people with a very high risk of the disease.
In this review article, we have discussed the role of CA125 in diagnosis, evaluating response to treatment and prognosis of ovarian cancer and provided some suggestions in improving the clinical utility of this biomarker in the early diagnosis of aggressive ovarian cancers.
The CA-125 blood test is used in ovarian cancer diagnosis and monitoring. Learn the normal range of cancer antigen 125, what is high and what causes fluctuations.
A retrospective multicentric study assessing the prognostic value of the serum CA125 assay in 225 patients with advanced epithelial ovarian cancer found that survival was significantly related to stage, residual disease, tumor grade, serum CA125 before the third cycle, and serum CA125 half-life.
Increased levels of CA 125 have been shown to be independent prognostic factors for survival in ovarian carcinoma. One study showed that patients with a preoperative CA 125 level above 65...
The half-life of the CA125 antigen is reported to have an additional prognostic value. A half-life of less than 20 days is associated with improved survival compared to a half-life of more than 20 days. [26] Normalization of CA125 levels after 3 cycles of combination therapy also correlates with improved survival.
If you have a high risk for ovarian cancer, your doctor may recommend that you have the CA-125 blood test along with a transvaginal ultrasound on a regular basis. 80% or more of women with...
The CA-125 blood test measures the amount of a specific protein called cancer antigen 125, or CA-125, in a person’s blood. Elevated CA-125 levels can suggest ovarian cancer, but they can also be caused by many benign conditions.
The objective of the current study was to determine the prognostic significance of a pretreatment serum CA 125 level in patients with advanced epithelial ovarian carcinoma (EOC) who received treatment with a standard chemotherapy regimen. METHODS: