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Oocyte abnormalities can be caused by a variety of genetic factors affecting different stages in meiosis. [1] Moreover, ageing is associated with oocyte abnormalities since higher maternal age is associated with oocytes with a reduced gene expression of spindle assembly checkpoints which are important in maintaining stability in the genome.
Poor ovarian reserve is a condition of low fertility characterized by 1): low numbers of remaining oocytes in the ovaries or 2) possibly impaired preantral oocyte development or recruitment.
An oocyte (/ ˈ oʊ ə s aɪ t /, oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction.In other words, it is an immature ovum, or egg cell.An oocyte is produced in a female fetus in the ovary during female gametogenesis.
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries.It secretes hormones that influence stages of the menstrual cycle.In humans, women have approximately 200,000 to 300,000 follicles at the time of puberty, [1] [2] each with the potential to release an egg cell (ovum) at ovulation for fertilization. [3]
Transvaginal oocyte retrieval (TVOR), also referred to as oocyte retrieval (OCR), is a technique used in in vitro fertilization (IVF) in order to remove oocytes from an ovary, enabling fertilization outside the body. [1]
Although about 1 million oocytes are present at birth in the human ovary, only about 500 (about 0.05%) of these ovulate, and the rest do not ovulate. The decline in ovarian reserve appears to occur at a constantly increasing rate with age, [ 17 ] and leads to nearly complete exhaustion of the reserve by about age 52.
Granulosa and theca cells continue to undergo mitosis concomitant with an increase in antrum volume. The Graaf follicle reaches its maximum diameter (20–22 mm) during ovulation. Antral follicles can attain a tremendous size that is hampered only by the availability of follicle stimulating hormone (FSH), on which it is dependent in this stage ...
Titus et al. [13] (2013) found that, as humans (and mice) age, expression of four key DNA repair genes necessary for homologous recombinational repair declines in oocytes. They hypothesized that DNA double-strand break repair is vital for the maintenance of oocyte reserve, and that a decline in efficiency of repair with age plays a key role in ...