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A lock and key is a pair of devices used to secure an object or location from unauthorized access. ... a model for the specificity of enzymes and other of biomolecules;
One can think of molecular docking as a problem of “lock-and-key”, in which one wants to find the correct relative orientation of the “key” which will open up the “lock” (where on the surface of the lock is the key hole, which direction to turn the key after it is inserted, etc.). Here, the protein can be thought of as the “lock ...
This is often referred to as "the lock and key" model. [1]: 8.3.2 This early model explains enzyme specificity, but fails to explain the stabilization of the transition state that enzymes achieve. [40]
Molecular imprinting is a technique to create template-shaped cavities in polymer matrices with predetermined selectivity and high affinity. [1] This technique is based on the system used by enzymes for substrate recognition, which is called the "lock and key" model.
A recent version of the previously named shape theory, also known as odotope theory or Weak Shape Theory, holds that a combination of activated receptors is responsible for any one smell, as opposed to the older model of one receptor, one shape, one smell. Receptors in the odotope model recognize only small structural features on each molecule ...
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The induced fit model is a development of the lock-and-key model and assumes that an active site is flexible and changes shape until the substrate is completely bound. This model is similar to a person wearing a glove: the glove changes shape to fit the hand. The enzyme initially has a conformation that attracts its substrate.
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