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Antidepressants, including SSRIs, can cross the placenta and have the potential to affect the fetus and newborn, including an increased chance of miscarriage, presenting a dilemma for pregnant women to decide whether to continue to take antidepressants at all, or if they do, considering if tapering and discontinuing during pregnancy could have ...
Use of antidepressants during pregnancy may result in fetus abnormalities affecting functional development of the brain and behavior. [90] Studies have shown correlations between pregnant women treated with SNRIs and risk of hypertensive disorders, [91] preeclampsia, [92] miscarriage, [93] seizures in children, [94] and many other adverse affects.
Another serious drawback of all antidepressants is the requirement for long-term administration prior to maximal therapeutic efficacy. Although some patients show a partial response within 1–2 weeks, in general one must reckon with a delay of 3–6 weeks before full efficacy is attained.
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It can take at least four weeks for this enzyme to be replaced by the body in the instance of irreversible inhibitors. [31] With respect to tricyclic antidepressants, only clomipramine and imipramine have a risk of causing SS. [32] Many medications may have been incorrectly thought to cause SS.
Women’s health expert Dr. Jennifer Wider tells Yahoo Life that “weeks 5 to 9 is the early time period in a pregnancy. At 5 weeks, the embryo is a mass of cells with a developing neural tube ...
SSRI use in pregnancy is associated with an increased risk of spontaneous abortion of about 1.7-fold. [141] [142] Use is also associated with preterm birth. [143] According to some researches, decreased body weight of the child, intrauterine growth retardation, neonatal adaptive syndrome, and persistent pulmonary hypertension also was noted. [144]
Antidepressant exposure is not associated with an increased risk of spontaneous abortion. [55] There is a tentative association of SSRI use during pregnancy with heart problems in the baby. [56] The advantages of their use during pregnancy may thus not outweigh the possible negative effects on the baby. [56]