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Podocytes are found lining the Bowman's capsules in the nephrons of the kidney. The pedicels or foot processes wrap around the glomerular capillaries to form the filtration slits. [ 7 ] The pedicels increase the surface area of the cells enabling efficient ultrafiltration .
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
An illustration of podocytes, which surround the glomerular capillaries with their cell bodies, primary processes and interdigitating foot processes. The podocyte is a highly specialised epithelial cell in Bowman's capsule in the kidney. Primary processes of the podocytes form terminal foot processes.
C. Podocytes: 1. enzymatic and structural proteins 2. filtration slit 3. diaphragma The main function of the glomerulus is to filter plasma to produce glomerular filtrate, which passes down the length of the nephron tubule to form urine.
C. Podocytes: 1. enzymatic and structural proteins 2. filtration slit 3. diaphragm. The renal corpuscle is the site of the filtration of blood plasma. The renal corpuscle consists of the glomerulus, and the glomerular capsule or Bowman's capsule. [4]: 1027 The renal corpuscle has two poles: a vascular pole and a tubular pole.
The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural component of the slit diaphragm. [5] It is present on the tips of the podocytes as an intricate mesh connecting adjacent foot processes.