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It was discovered in 2000 as one of two improved mutants by H. Bujard and his colleagues after random mutagenesis of the Tet repressor part of the transactivator gene. [6] Tet-On 3G (also known as rtTA-V10 [7]) is similar to Tet-On Advanced but was derived from rtTA2 S-S2 rather than rtTA2 S-M2. It is also human codon optimized and composed of ...
Its transactivator, Tax, can interact with p40, inducing overexpression of interleukin 2, interleukin receptors, GM-CSF and the transcription factor c-Fos. HTLV infects T-cells and via the increased expression of these stimulatory cytokines and transcription factors , leads to uncontrolled proliferation of T-cells and hence lymphoma .
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene.Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation, [5] [6] but is expressed as different isoforms which may have distinct functions.
Thus TET enzymes largely initiate demethylation at 5mCpG sites. Oxoguanine glycosylase (OGG1) is one example of a protein that recruits a TET enzyme. TET1 is able to act on 5mCpG if an ROS has first acted on the guanine to form 8-hydroxy-2'-deoxyguanosine (8-OHdG or its tautomer 8-oxo-dG), resulting in a 5mCp-8-OHdG dinucleotide (see Figure). [10]
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. [5] [6] Telomerases are part of a distinct subgroup of RNA-dependent polymerases.
194388 Ensembl ENSG00000187605 ENSMUSG00000034832 UniProt O43151 Q8BG87 RefSeq (mRNA) NM_001287491 NM_001366022 NM_183138 NM_001347313 RefSeq (protein) NP_001274420 NP_001352951 NP_001334242 NP_898961 Location (UCSC) Chr 2: 73.98 – 74.11 Mb Chr 6: 83.34 – 83.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tet methylcytosine dioxygenase 3 is a protein that in humans is encoded ...
[2] [3] Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery to the promoter, therefore increasing gene expression. [ 3 ] [ 4 ] [ 5 ] The use of activators and coactivators allows for highly specific expression of certain genes depending on cell type and developmental stage.
54790 214133 Ensembl ENSG00000168769 ENSMUSG00000040943 UniProt Q6N021 Q4JK59 RefSeq (mRNA) NM_001127208 NM_017628 NM_001040400 NM_145989 NM_001346736 RefSeq (protein) NP_001120680 NP_060098 NP_001035490 NP_001333665 Location (UCSC) Chr 4: 105.15 – 105.28 Mb Chr 3: 133.17 – 133.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tet methylcytosine dioxygenase 2 (TET2) is a human ...