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Ciclopirox is a medication used for the treatment of moderate onychomycosis of fingernails and toenails, [3] and for the treatment of seborrheic dermatitis. [ 4 ] In 2022, it was the 247th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
[8] Miconazole Miconazole is a widely used topical antifungal medication for the treatment of many fungal infections, namely skin infections, nail infections and vaginal candidiasis. The drug is usually formulated in creams, powders and sprays. However, it is suggested that patients developing acute porphyrias should avoid using this drug.
Topical ciclopirox results in a cure in 6% to 9% of cases. [2] [31] Ciclopirox when used with terbinafine appears to be better than either agent alone. [2] Although eficonazole, P-3051 (ciclopirox 8% hydrolacquer), and tavaborole are effective at treating fungal infection of toenails, complete cure rates are low. [36]
In two clinical trials 17.8% (trial 1) and 15.2% (trial 2) of participants using efinaconazole were completely cured (0% clinical involvement of the target toenail, plus negative KOH test and negative culture), compared with 3.3% (trial 1) and 5.5% (trial 2) of participants using a placebo. [2]
The chain began in 1912 [2] and grew to 46 stores by 1946 and over 100 by the 1970s. [3] [4] Besides Ohio, stores later opened in Florida and Maryland. [5] The chain later acquired Alexandria, Virginia-based Drug Fair in 1981, shortly before Sherwin-Williams bought the chain. Gray Drug acquired several Cunningham Drug stores in 1982. [2]
The store in Portsmouth, Ohio (adjacent to a Harts Department Store) was one such example. Over time, Big Bear became a major supermarket chain in Ohio and West Virginia . In July 1988, the company started its hyperstore Big Bear Plus concept in Wintersville, Ohio (140,000 sq ft (13,000 m 2 )), and Bridgeport, Ohio (100,000 sq ft (10,000 m 2 ...