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The revised five-factor score is associated with five-year mortality from GPA and is based on these criteria: Age greater than 65 years, cardiac symptoms, gastrointestinal involvement, chronic kidney disease, and the absence of ear, nose, and throat symptoms. [7] With corticosteroids and cyclophosphamide, five-year survival is over 80%. [13]
The diagnosis requires consistent symptoms with two additional signs: [citation needed] Chest X-ray or CT scan showing evidence of right middle lobe (or left lingular lobe) lung infection; Sputum culture or bronchoalveolar lavage culture demonstrating the infection is caused by MAC; Disseminated MAC is most readily diagnosed by one positive ...
Sarcoidosis (/ ˌ s ɑːr k ɔɪ ˈ d oʊ s ɪ s /; also known as Besnier–Boeck–Schaumann disease) is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomata. [2] The disease usually begins in the lungs, skin, or lymph nodes. [2]
Eosinophilic granulomatosis with polyangiitis consists of three stages, but not all patients develop all three stages or progress from one stage to the next in the same order; [7] whereas some patients may develop severe or life-threatening complications such as gastrointestinal involvement and heart disease, some patients are only mildly affected, e.g. with skin lesions and nasal polyps. [8]
The most common benign coin lesion is a granuloma (inflammatory nodule), for example due to tuberculosis or a fungal infection, such as Coccidioidomycosis. [6] Other infectious causes include a lung abscess, pneumonia (including pneumocystis pneumonia) or rarely nocardial infection or worm infection (such as dirofilariasis or dog heartworm ...
Granulomatous–lymphocytic interstitial lung disease (GLILD) is a lung complication of common variable immunodeficiency disorders (CVID). It is seen in approximately 15% of patients with CVID. [ 1 ] It has been defined histologically as the presence of (non-caseating) granuloma and lymphoproliferation in the lung. [ 1 ]
Hallmark finding of disease is a widened mediastinum visualized on chest x-ray. Once clinical symptoms of anthrax induced mediastinitis appear, disease is nearly 100% fatal. Individuals with known exposure to spores may be treated prophylactically with antibiotics (fluoroquinolones or tetracycline) to prevent disease progression.
Palisaded neutrophilic and granulomatous dermatitis (PNGS) is usually associated with a well-defined connective tissue disease, lupus erythematosus or rheumatoid arthritis most commonly, and often presents with eroded or ulcerated symmetrically distributed umbilicated papules or nodules on the elbows.