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With further reports of the increased risk of kidney injury with prolonged and excessive phenacetin use, however, phenacetin was banned in several countries between the 1960s and 1980s. [20] As the use of phenacetin declined, so too did the prevalence of analgesic nephropathy as a cause of end-stage kidney disease.
However, it became recognised that these medications were addictive, and Priscilla Kincaid-Smith found that the large doses of phenacetin ingested by habitual users were responsible for widespread kidney disease. [4] [5] The phenacetin was removed from Bex in 1975. [6] Bex has also been linked to kidney cancer. [7]
In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases. [13] In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis , or dissolution of blood cells, while taking this drug.
In 1966, phenacetin was substituted with aloxiprin due to several cases linking it to kidney failure. It was also acknowledged that the product was somewhat addictive, echoed in their logo "Askit fights the miseries". Heavily addicted individuals in the pre-66 formula risked kidney failure. [5]
But there have also been reports of individuals taking GLP-1 medications, like semaglutide, who developed kidney issues, including worsening chronic kidney failure, especially if experiencing ...
Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II's vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma volume, and thereby RPF)—the so-called "triple whammy" effect. [82] In rarer instances NSAIDs may also cause more severe kidney ...