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Gastrointestinal side-effects lead to discontinuation of the drug in 2% to 8% of people using varenicline. [19] [20] Incidence of nausea is dose-dependent: incidence of nausea was higher in people taking a larger dose (30%) versus placebo (10%) as compared to people taking a smaller dose (16%) versus placebo (11%). [5]
Giving up smoking is associated with an average weight gain of 4–5 kilograms (8.8–11.0 lb) after 12 months, most of which occurs within the first three months of quitting. [200] The possible causes of the weight gain include: Smoking over-expresses the gene AZGP1 which stimulates lipolysis, so smoking cessation may decrease lipolysis. [201]
Gestational diabetes is a form of diabetes that is first diagnosed during pregnancy and can accordingly cause high blood sugar that affects the woman and the baby. [9] In 10 - 20% of women whose diet and exercise are not adequate enough to control blood sugar, insulin injections may be required to lower blood sugar levels. [9]
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. (Reminder that there are many of these meds now.
Weight gain. Some side effects, such as weight gain, occur more frequently with certain types of antidepressant medication. Switching to a new type of antidepressant may help reverse any weight ...
The first study makes only a passing mention to psychiatric side effects (at least in the abstract) noting that they are "unproven." The second, more importantly, shows a moderate incidence of psychiatric side effects (something like 1.1%), with two participants in the study attempting suicide during its course.
These gastrointestinal side effects tend to be more common during the first few weeks of treatment or while the patient adjusts to an increased dose. Deposit Photos Severe Side Effects of Ozempic
Bupropion, when used for treating long-term weight gain over six to twelve months, results in an average weight loss of 2.7 kilograms (6.0 lb) over placebo. [74] This is not much different from the weight loss produced by several other weight-loss medications such as sibutramine or orlistat . [ 74 ]