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Overactive bladder affects approximately 11% of the population and more than 40% of people with overactive bladder have incontinence. [5] [6] Conversely, about 40% to 70% of urinary incontinence is due to overactive bladder. [7] Overactive bladder is not life-threatening, [1] but most people with the condition have problems for years. [1]
The chemical structure of Solabegron, a β 3-adrenergic receptor agonist. Mirabegron is a selective β 3-AR agonist that affects the detrusor muscles of the urinary bladder.By stimulation of β 3-AR the contraction of the smooth muscles of the bladder is decreased and the bladder can store more volume of urine at a given time.
Oxybutynin, sold under the brand name Ditropan among others, is an anticholinergic medication primarily used to treat overactive bladder.It is widely considered a first-line therapy for overactive bladder due to its well-studied side effect profile, broad applicability, and continued efficacy over long periods of time.
Percutaneous tibial nerve stimulation (PTNS), also referred to as posterior tibial nerve stimulation, is the least invasive form of neuromodulation used to treat overactive bladder (OAB) and the associated symptoms of urinary urgency, urinary frequency and urge incontinence.
Solifenacin, sold as the brand name Vesicare [a] among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). [1] [2] It may help with incontinence, urinary frequency, and urinary urgency.
Trospium chloride is used for the treatment of overactive bladder with symptoms of urge incontinence and frequent urination. [3] [4] [2]It should not be used with people who retain urine, who have severe digestive conditions, myasthenia gravis, narrow-angle glaucoma, or tachyarrhythmia.