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Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. [5] This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections and hydatid disease, among others. [5] It has been used for treatment of giardiasis but is not a preferred agent.
The narcotizing effect immobilizes the worm, which prevents migration when treatment is accomplished with weak drugs such as thiabendazole. If used by itself it causes the worm to be passed out in the feces. Dosage is 75 mg/kg (max 3.5 g) as a single oral dose. [citation needed]
Diagnosis is by seeing the worms which are about one centimetre long or the eggs under a microscope. [1] [6] Treatment is typically with two doses of the medications mebendazole, pyrantel pamoate, or albendazole two weeks apart. [4] Everyone who lives with or takes care of an infected person should be treated at the same time. [1]
During this migration, they moult twice and become adults. [19] [21] Females survive for 5 to 13 weeks, and males about 7 weeks. [19] The male and female pinworms mate in the ileum (i.e., last part of the small intestine), [19] whereafter the male pinworms usually die, [23] and are passed out with stool. [24]
Once in the host gut, Necator tends to cause a prolonged infection, generally 1 to 5 years (many worms die within a year or two of infection), though some adult worms have been recorded to live for 15 years or more. Ancylostoma adults are short-lived, surviving on average for only about 6 months. However, the infection can be prolonged because ...
Once in the trachea, the worms are coughed up into the pharynx and then swallowed again, after which they pass through the stomach and into the small intestine, where they mature into adult worms. [5] [7] The adult worms begin producing fertilized eggs within 60–65 days of being swallowed; [7] females produce as many as 200,000 eggs per day ...