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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
The long-term impact of alcohol on the brain has become a growing area of research focus. While researchers have found that moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence, [1] excessive alcohol consumption is associated with widespread and significant brain lesions.
Alcohol is a potent neurotoxin. [5] The National Institute on Alcohol Abuse and Alcoholism has found, "Alcoholism may accelerate normal aging or cause premature aging of the brain." [6] Another report by the same agency found, "Chronic alcohol consumption, as well as chronic glucocorticoid exposure, can result in premature and/or exaggerated ...
Chronic consumption of alcohol (defined as greater than 80 g per day for at least 5 years) can lead to multi-organ failure, including myocardial dysfunction. [7] The exact pathophysiologic mechanism by which chronic consumption of alcohol causes DCM is not well understood, however it's believed that genetic mutation, and mitochondrial damage ...
The level of ethanol consumption that minimizes the risk of disease, injury, and death is subject to some controversy. [16] Several studies have found a J-shaped relationship between alcohol consumption and health, [17] [18] [2] [19] meaning that risk is minimized at a certain (non-zero) consumption level, and drinking below or above this level increases risk, with the risk level of drinking a ...
Consuming a few drinks may make you feel desensitized to love-making and delay finishing, although these findings were from one small study of 24 men and women. Alcohol consumption can also ...
Of 29 alcohol abusers in the College sample, seven men were able to drink heavily for a mean of three decades without showing symptoms of dependence. The average age of onset of alcohol abuse was 29 years for the Core City men and 41 years for the College men.
Alcohol-related dementia is a broad term currently preferred among medical professionals. [10] If a person has alcohol-related 'dementia' they will struggle with day-to-day tasks. This is because of the damage to their brain, caused by regularly drinking too much alcohol over many years. [17] This affects memory, learning and other mental ...