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An estimated 4.4 percent of the global population has depression, according to a report released by the UN World Health Organization (WHO), which shows an 18 percent increase in the number of people living with depression between 2005 and 2015. [66] [67] [68] Depression is a major mental-health cause of disease burden.
Depressed people also have a higher rate of dying from other causes. [268] There is a 1.5- to 2-fold increased risk of cardiovascular disease , independent of other known risk factors, and is itself linked directly or indirectly to risk factors such as smoking and obesity.
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
The cause of depression is believed to be due to a combined effect of genetic and environmental factors. [11] Other medical conditions, for example hypothyroidism, may cause people to experience similar symptoms as a major depressive episode. [20]
For instance, a depressed person may feel better in terms of their energy and sleep, but still have negative, ruminating thoughts. People may also relapse into suicidal thinking after long ...
Depression (kinesiology), an anatomical term of motion, refers to downward movement, the opposite of elevation; Depression (physiology), a reduction in a biological variable or the function of an organ; Central nervous system depression, physiological depression of the central nervous system that can result in loss of consciousness
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