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Alpha 1 blockers cause vasodilation by relaxing smooth muscles that control blood vessel diameter, leading to lower blood pressure. [1] FDA-approved uses of these drugs include treating conditions like benign prostatic hyperplasia, hypertension, pheochromocytoma, extravasation management, and reversal of local anesthesia.
Drugs with muscarinic antagonist activity are widely used in medicine, in the treatment of low heart rate, overactive bladder, respiratory problems such as asthma and chronic obstructive pulmonary disease (COPD), and neurological problems such as Parkinson's disease and Alzheimer's disease.
Thus, alpha1 blockers can dilate blood vessels and decrease the blood pressure. [3] Depending on its site of action, it can be used to treat different diseases. [ 3 ] They can be used to treat signs and symptoms of benign prostatic hyperplasia , hypertension (but not as first line agent), pheochromocytoma , extravasation management and reversal ...
One type of medication used to treat acute migraine is triptans, which ultimately helps constrict blood vessels and block pain signals to improve migraine symptoms.
The blood–brain barrier is formed by special tight junctions between endothelial cells lining brain blood vessels. Blood vessels of all tissues contain this monolayer of endothelial cells, however only brain endothelial cells have tight junctions preventing passive diffusion of most substances into the brain tissue. [1]
Beta blockers vary in their lipophilicity (fat solubility) and in turn in their ability to cross the blood–brain barrier and exert effects in the central nervous system. [76] Beta blockers with greater blood–brain barrier permeability can have both neuropsychiatric therapeutic benefits and side effects, as well as adverse cognitive effects ...
Atherosclerosis is characterized by the build-up of plaque inside your blood vessels. It can lead to stenosis, which is a narrowing of your artery walls. Plaque is a fatty substance made up of:
The medication is designed to constrict blood vessels, explains Jamie Alan, Ph.D., an associate professor of pharmacology and toxicology at Michigan State University. “In congestion, this will ...