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Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. [1] Symptoms may include frequent urination , trouble starting to urinate, weak stream, inability to urinate , or loss of bladder control . [ 1 ]
[1] [3] Other treatments may include medication to decrease the size of the prostate, urethral dilation, a urethral stent, or surgery. [1] Males are more often affected than females. [1] In males over the age of 40 about 6 per 1,000 are affected a year. [1] Among males over 80 this increases 30%. [1]
Dutasteride is used for treating BPH, colloquially known as an "enlarged prostate". [ 9 ] [ 14 ] It is approved by the Food and Drug Administration (FDA) in the U.S. for this indication. [ 15 ] A 2010 Cochrane review found a 25–26% reduction in the risk of developing prostate cancer with 5α-reductase inhibitor chemoprevention .
This condition occurs in people who have a blockage of the bladder outlet (benign prostatic hyperplasia, prostate cancer, or narrowing of the urethra), or when the muscle that expels urine from the bladder is too weak to empty the bladder normally. Overflow incontinence may also be a side effect of certain medications.
Silodosin, sold under the brand name Urief among others, is a medication used for the symptomatic treatment of benign prostatic hyperplasia. [4] [5] It acts as an alpha-1 adrenergic receptor antagonist. [4] [5] The most common side effect is a reduction in the amount of semen released during ejaculation. [5]
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