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Radial glia are now recognized as key progenitor cells in the developing nervous system. During the late stages of neurogenesis, radial glial cells divide asymmetrically in the ventricular zone, generating a new radial glial cell, as well as a postmitotic neuron or an intermediate progenitor (IPC) daughter cell.
The radial glial cells are disposed in planes perpendicular to the axes of ventricles. One of their processes abuts the pia mater , while the other is deeply buried in gray matter. Radial glia are mostly present during development, playing a role in neuron migration .
Within each developing radial unit, the process of neurogenesis gives rise to post-mitotic (non-dividing) cortical neurons, which begin the process of radial neuronal migration from the ventricular zone and adjacent subventricular zone to form the cortical plate in the classic 'inside-out' manner beginning with the deep cortical layers.
The progenitor cells and radial glial cells respond to extracellular trophic factors - like ciliary neurotrophic factor (CNTF), cytokines or neuregulin 1 (NRG1) - that can determine whether the cells will differentiate into either neurons or glia. [5]
These early stem cells are called neuroepithelial cells (NEC)s, but soon take on a highly elongated radial morphology and are then known as radial glial cells (RGC)s. [3] RGCs are the primary stem cells of the mammalian CNS, and reside in the embryonic ventricular zone , which lies adjacent to the central fluid-filled cavity ( ventricular ...
Radial glial cells, also called radial glial progenitor cells, divide asymmetrically to produce a neuroblast and another radial glial cell that will re-enter the cell cycle. [5] [3] This mitosis occurs in the germinal neuroepithelium (or germinal zone), when a radial glial cell divides to produce the neuroblast. The neuroblast detaches from the ...
The cerebral cortex is divided into layers. Each layer is formed by radial glial cells located in the ventricular zone or subventricular zone, and then migrate to their final destination. [8] Layers of the cerebral cortex, oriented from most superficial (top of image) to deepest (bottom of image).
Neoplastic glial cells stained with an antibody against GFAP (brown), from a brain biopsy. While glial cells in the PNS frequently assist in regeneration of lost neural functioning, loss of neurons in the CNS does not result in a similar reaction from neuroglia. [18] In the CNS, regrowth will only happen if the trauma was mild, and not severe. [40]