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  2. Granulosa cell - Wikipedia

    en.wikipedia.org/wiki/Granulosa_cell

    Cell culture of granulosa cells can be performed in vitro. Plating density (number of cells per volume of culture medium) plays a critical role for the differentiation. A lower plating density makes granulosa cells exhibit estrogen production, while a higher plating density makes them appear as progesterone producing theca lutein cells. [12]

  3. Theca of follicle - Wikipedia

    en.wikipedia.org/wiki/Theca_of_follicle

    The anterior pituitary complex and hypophyseal portal system, where FSH and LH are released. Theca cells are responsible for synthesizing androgens, providing signal transduction between granulosa cells and oocytes during development by the establishment of a vascular system, providing nutrients, and providing structure and support to the follicle as it matures.

  4. Theca interna - Wikipedia

    en.wikipedia.org/wiki/Theca_interna

    Theca interna cells express receptors for luteinizing hormone (LH) to produce androstenedione, which via a few steps, gives the granulosa the precursor for estrogen manufacturing. [1] After rupture of the mature ovarian follicle, the theca interna cells differentiate into the theca lutein cells of the corpus luteum.

  5. Corpus luteum - Wikipedia

    en.wikipedia.org/wiki/Corpus_luteum

    The granulosa lutein cells do have aromatase, and use it to produce estrogens, using the androgens previously synthesized by the theca lutein cells, as the granulosa lutein cells in themselves do not have the 17α-hydroxylase or 17,20 lyase to produce androgens. [5] Once the corpus luteum regresses the remnant is known as corpus albicans. [12]

  6. Folliculogenesis - Wikipedia

    en.wikipedia.org/wiki/Folliculogenesis

    Dormant, small, only one layer of flat granulosa cells: Primordial follicles are about 0.03–0.05 mm in diameter. Primary: Mitotic cells, cuboidal granulosa cells: Almost 0.1 mm in diameter Secondary: Presence of theca cells, multiple layers of granulosa cells: The follicle is now 0.2 mm in diameter Early tertiary

  7. Follicular phase - Wikipedia

    en.wikipedia.org/wiki/Follicular_phase

    FSH induces the proliferation of granulosa cells in the developing follicles, and the expression of luteinizing hormone (LH) receptors on these granulosa cells (Figure 1). Under the influence of FSH, aromatase and p450 enzymes are activated, causing the granulosa cells to begin to secrete estrogen.

  8. Activin and inhibin - Wikipedia

    en.wikipedia.org/wiki/Activin_and_inhibin

    FSH stimulates the secretion of inhibin from the granulosa cells of the ovarian follicles in the ovaries. In turn, inhibin suppresses FSH. Inhibin B reaches a peak in the early- to mid-follicular phase, and a second peak at ovulation. Inhibin A reaches its peak in the mid-luteal phase.

  9. Membrana granulosa - Wikipedia

    en.wikipedia.org/wiki/Membrana_granulosa

    The larger ovarian follicles consist of an external fibrovascular coat, connected with the surrounding stroma of the ovary by a network of blood vessels, and an internal coat, which consists of several layers of nucleated cells, called the membrana granulosa. It contains numerous granulosa cells.