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The American Journal of Alzheimer's Disease & Other Dementias is a peer-reviewed academic journal that publishes papers in the field of neurology. The journal's editor is Carol F. Lippa, MD (Drexel University College of Medicine). It has been in publication since 1986 and is currently published by SAGE Publications.
Alois Alzheimer is often credited with first linking plaques to dementia in a 1906 presentation (published in 1907), [12] but this short report focused mainly on neurofibrillary tangles, and plaques were only briefly mentioned. [4] Alzheimer's first substantive description of plaques appeared in 1911. [11]
Familial Alzheimer's disease mutations commonly used in animal models. Rodent animal models of Alzheimer's disease are commonly used in research as rodents and humans have many of the same major brain regions and neurotransmitter systems. [5] These models are small, easy to house, as well as breed very well. [26]
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. [2] It is the cause of 60–70% of cases of dementia. [2] [15] The most common early symptom is difficulty in remembering recent events. [1]
Alois Alzheimer (/ ˈ æ l t s h aɪ m ər / ALTS-hy-mər, US also / ˈ ɑː l t s-, ˈ ɔː l t s-/ AHLTS-, AWLTS-, [1] [2] German: [ˈaːlɔɪs ˈʔaltshaɪmɐ]; 14 June 1864 – 19 December 1915) was a German psychiatrist, neuropathologist and colleague of Emil Kraepelin.
Since dementia patients have trouble communicating their needs, this can be frustrating for the nurse. Nurses may have a hard time forming relationships with their dementia patients because of the communication barrier. How the dementia patient feels is based on their social interactions, and they may feel neglected because of this barrier. [35]
Studies have shown that Alzheimer's disease (AD) patients are at an increased risk of morbidity and mortality from SARS-CoV-2, the virus that causes COVID-19. [1] AD is the most common cause of dementia worldwide and is clinically defined by amyloid beta plaques, neurofibrillary tangles, and activation of the brain's immune system.
Brain Aβ is elevated in people with sporadic Alzheimer's disease. Aβ is the main constituent of brain parenchymal and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic. [ 33 ] [ 34 ] [ 35 ] It is unresolved how Aβ accumulates in the central nervous system and subsequently initiates the disease of cells.