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  2. Adrenal cortex - Wikipedia

    en.wikipedia.org/wiki/Adrenal_cortex

    The adrenal cortex is the outer region and also the largest part of the adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones. It is also a secondary site of androgen synthesis. [2]

  3. Adrenal gland - Wikipedia

    en.wikipedia.org/wiki/Adrenal_gland

    The adrenal gland secretes a basal level of cortisol but can also produce bursts of the hormone in response to adrenocorticotropic hormone (ACTH) from the anterior pituitary. Cortisol is not evenly released during the day – its concentrations in the blood are highest in the early morning and lowest in the evening as a result of the circadian ...

  4. Adrenocortical hormone - Wikipedia

    en.wikipedia.org/wiki/Adrenocortical_hormone

    In humans and other animals, the adrenocortical hormones are hormones produced by the adrenal cortex, the outer region of the adrenal gland.These polycyclic steroid hormones have a variety of roles that are crucial for the body's response to stress (for example, the fight-or-flight response), and they also regulate other functions in the body.

  5. Cortisol - Wikipedia

    en.wikipedia.org/wiki/Cortisol

    Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone. When used as medication, it is known as hydrocortisone. It is produced in many animals, mainly by the zona fasciculata of the adrenal cortex in an adrenal gland. [1] In other tissues, it is produced in lower quantities. [2]

  6. Neuroendocrinology - Wikipedia

    en.wikipedia.org/wiki/Neuroendocrinology

    Today, neuroendocrinology embraces a wide range of topics that arose directly or indirectly from the core concept of neuroendocrine neurons. Neuroendocrine neurons control the gonads, whose steroids, in turn, influence the brain, as do corticosteroids secreted from the adrenal gland under the influence of adrenocorticotrophic hormone. The study ...

  7. Hypothalamic–pituitary–adrenal axis - Wikipedia

    en.wikipedia.org/wiki/Hypothalamic–pituitary...

    Schematic of the HPA axis (CRH, corticotropin-releasing hormone; ACTH, adrenocorticotropic hormone) Hypothalamus, pituitary gland, and adrenal cortex The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus (a part of the brain located below the thalamus), the pituitary gland (a ...

  8. Zona fasciculata - Wikipedia

    en.wikipedia.org/wiki/Zona_fasciculata

    The zona fasciculata chiefly produces glucocorticoids (mainly cortisol in humans), which regulate the metabolism of glucose. Glucocorticoid production is stimulated by adrenocorticotropic hormone (ACTH) [ 1 ] , which is released from the anterior pituitary , especially in times of stress as part of the fight-or-flight response .

  9. Zona reticularis - Wikipedia

    en.wikipedia.org/wiki/Zona_reticularis

    In humans, the reticularis layer does contain 17α-hydroxylase; this hydroxylates pregnenolone, which is then converted to cortisol by a mixed function oxidase. Deficiency of 17α-hydroxylase results in low blood levels of estrogens, androgens, and cortisol, and the resultant compensatory increases in adrenocorticotrophic hormone stimulates the ...