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The therapeutic recommended dosages were 12.5, 25, and 50 mg with an approximate bioavailability of 93%. [12] [13] [14] Rofecoxib crossed the placenta and blood–brain barrier, [12] [13] [15] and took 1–3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) around 17 hours.
In September 2001, the United States Food and Drug Administration (FDA) sent a warning letter to the CEO of Merck, stating, "Your promotional campaign discounts the fact that in the VIGOR study, patients on Vioxx were observed to have a four to five fold increase in myocardial infarctions (MIs) compared to patients on the comparator ...
Download QR code; Print/export Download as PDF; Printable version; In other projects Wikidata item; Appearance. ... COPX - CanadianOxy Industrial Chemicals, LP;
Daisy Fancourt (born June 1990 [2]) is a British researcher who is a professor of psychobiology and epidemiology at University College London. [3] [4] [5] [6] Her ...
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The Global Initiative for Chronic Obstructive Lung Disease (GOLD) is a non-profit organization started by the World Health Organization and the US National Heart, Lung, and Blood Institute in 1997 to improve care for chronic obstructive pulmonary disease (COPD).
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