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The enzymatic activity of the RAG proteins is concentrated largely in a core region; Residues 384–1008 of RAG-1 and residues 1–387 of RAG-2 retain most of the DNA cleavage activity. The RAG-1 core contains three acidic residues (D 600, D 708, and E 962) in what is called the DDE motif, the major active site for DNA cleavage. These residues ...
Many terms are used to refer to people who salvage recyclables from the waste stream for sale or personal consumption. In English, these terms include rag picker, reclaimer, informal resource recoverer, binner, recycler, poacher, salvager, scavenger, and waste picker; in Spanish cartonero, chatarrero, pepenador, clasificador, minador and reciclador; and in Portuguese catador de materiais ...
Retrieval Augmented Generation (RAG) is a technique that grants generative artificial intelligence models information retrieval capabilities. It modifies interactions with a large language model (LLM) so that the model responds to user queries with reference to a specified set of documents, using this information to augment information drawn from its own vast, static training data.
Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene. [ 5 ] The RAG1 and RAG2 genes are largely conserved in humans. 55.99% and 55.98% of the encoded amino acids contain no reported variants, respectively.
The Ragulator-Rag complex is a regulator of lysosomal signalling and trafficking in eukaryotic cells, which plays an important role in regulating cell metabolism and growth in response to nutrient availability in the cell. [1] The Ragulator-Rag Complex is composed of five LAMTOR subunits, which work to regulate MAPK and mTOR complex 1. [2]
A warning has been issued to travelers over the spread of three diseases, including the Marburg virus. It’s a close cousin of Ebola that’s been dubbed the “bleeding eye” virus due to one ...
This sweater and wide-leg pant set looks way more high-end than the price suggests. The slouchy oversized silhouette is the perfect comfy, ready-for-a-cozy-day-at-home fit.
Stub sorters are frequently faced with cases of editorial boldness which have left messes that they have to clear up, diverting them from more productive work. A major reason for the seemingly nit-picking nature of stub sorters is an attempt to get things as near perfect as possible the first time, thereby avoiding the need for more work later.