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JAM-1 was the first of the junctional adhesion molecules to be discovered, and is located in the tight junctions of both epithelial and endothelial cells. [8] JAM-1interacts with cells in a homophilic manner in order to preserve the structure of the junction while moderating its permeability.
These molecules are an invaluable part of cellular communication, as a single ligand can be used for many integrins. Unfortunately, these molecules still have a long way to go in the ways of research. [20] Immunoglobulin superfamily are a group of calcium independent proteins capable of homophilic and heterophilic adhesion. Homophilic adhesion ...
Junctional adhesion molecules are divided in subgroups according to their composition and binding motif. Glycosylated transmembrane proteins JAMs are classified in the immunoglobulin superfamily, that are formed by two extracellular Ig-like domains: the transmembrane region and the C-terminal cytoplasmatic domain. Members of this JAM family ...
Junctional Adhesion Molecules are part of the immunoglobulin superfamily. They have a molecular weight of ~40 to 48 kDa. [11] Their structure differs from that of the other integral membrane proteins in that they only have one transmembrane domain instead of four.
Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. [5] [6] [7] JAM2 has also been designated as CD322 (cluster of differentiation ...
The four main transmembrane proteins are occludin, claudin, junctional adhesion molecules (JAMs) and tricellulins. The extracellular domains of these proteins form the tight junction barrier by making homophilic (between proteins of the same kind) and heterophilic interactions (between different types of proteins) with the protein domains on ...
Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. [5] [6] [7] It has also been designated as CD321 (cluster of differentiation 321).