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Periarteriolar lymphoid sheaths (or periarterial lymphatic sheaths, or PALS) are a portion of the white pulp of the spleen.They are populated largely by T cells and surround central arteries within the spleen; the PALS T-cells are presented with blood borne antigens via myeloid dendritic cells.
The cords of Billroth (also known as splenic cords or red pulp cords) are found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages.
Micrograph of the spleen showing darkly stained, spheroid Gamna-Gandy bodies (arrows) outside the vessel wall at the center. Also shown is diffusely scattered, brown, granular hemosiderin pigment (arrowheads), indicating previous hemorrhage (hematoxylin & eosin staining, 40x magnification).
The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the liver and tissue histiocytes are also part of the MPS. The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one.
White pulp, splenic lymphoid nodules, or white nodules — follicles in the white pulp of the spleen, containing many lymphocytes; These structures are named after Marcello Malpighi (1628–1694), an Italian physician and biologist regarded as the father of microscopical anatomy and histology
Schweigger-Seidel sheath is a phagocytic sleeve that is part of a sheathed arteriole of the spleen, and is sometimes referred to as a splenic ellipsoid. It is a spindle-shaped thickening in the walls of the second part of the arterial branches forming the penicilli in the spleen. It is named after German physiologist Franz Schweigger-Seidel ...
Enlargement of the spleen is a requirement for the diagnosis of SMZL and is seen in nearly all people affected by SMZL (often without lymphadenopathy). [1] Aside from the uniform involvement of the spleen, the bone marrow is frequently positive in patients with SMZL displaying a nodular pattern with morphology similar to what is observed in the splenic hilar lymph nodes. [7]
The trabecular arteries are the name of the branches of the splenic artery after it passes into the trabeculae of the spleen, where it branches.When these arteries then reach the white pulp, and become covered with periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles).