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It is a progestin that is also used in combination with ethinylestradiol, an estrogen, as a vaginal ring under the brand names NuvaRing and Circlet. [14] Etonogestrel is effective as a means of birth control and lasts at least three or four years with some data showing effectiveness for five years. [9] [11] Following removal, fertility quickly ...
A contraceptive implant is an implantable medical device used for the purpose of birth control.The implant may depend on the timed release of hormones to hinder ovulation or sperm development, the ability of copper to act as a natural spermicide within the uterus, or it may work using a non-hormonal, physical blocking mechanism.
A positive characteristic of IUDs is that fertility and the ability to become pregnant returns quickly once the IUD is removed. [13] Because of their systemic nature, hormonal methods have the largest number of possible side effects. [14] Combined hormonal contraceptives contain estrogen and progestin hormones. [15]
The ring is placed into the vagina for a three-week period, then removal of the ring for one week, during which the user will experience a menstrual period.The break week is comparable to the placebo week for combined oral birth control pills ("the Pill"), and the birth control effect is maintained during this period.
In particular, the oral route is subject to a high first-pass effect, which results in high levels of estradiol and consequent estrogenic effects in the liver and low potency due to first-pass hepatic and intestinal metabolism into metabolites like estrone and estrogen conjugates. [10]
Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).
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