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Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent , and gadolinium (Gd 3+ ), and is used in form of the meglumine salt (gadoterate meglumine).
The most severe reaction to gadobutrol is nephrogenic system fibrosis (NSF) among patients with impaired elimination of the drug. The risk is highest among patients with chronic, impaired kidney function and those with acute kidney injury. NSF may result in death or severe impairment of the skin, muscle, and internal organs. [8]
Gadoxetic acid is a gadolinium-based MRI contrast agent. [4] Its salt, gadoxetate disodium , is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals .
The World Health Organization issued a restriction on use of several gadolinium contrast agents in November 2009 stating that "High-risk gadolinium-containing contrast agents (Optimark, Omniscan, Magnevist, Magnegita, and Gado-MRT ratiopharm) are contraindicated in patients with severe kidney problems, in patients who are scheduled for or have ...
High levels of niacin, an essential B vitamin, may raise the risk of heart disease by triggering inflammation and damaging blood vessels, according to new research. This type of supplement may ...
The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations. The tetracarboxylic acid was first reported in 1976. [2] At the time of its discovery DOTA exhibited the largest known formation constant for the complexation of Ca 2+ and Gd 3+ ions. Modified ...
No cases have been seen in people with normal kidney function. [7] A 2015 study found gadolinium deposited in the brain tissue of people who had received gadodiamide. [8] Other studies using post-mortem mass spectrometry found most of the deposit remained at least 2 years after an injection and deposit also in individuals with no kidney issues.
Salvesterols have been marketed as dietary supplements promoted for their supposed anti-cancer abilities. According to Andy Lewis, publisher of The Quackometer Blog , "there is no evidence to suggest that these plant-derived chemicals have any positive effect on reducing cancer risk when taken in supplement form or for forming any part of a ...
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