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This post-translational modification occurs in all animals and bromine is an essential trace element for humans. [19] Eosinophils need bromide for fighting multicellular parasites. Hypobromite is produced via eosinophil peroxidase, an enzyme that can use chloride but preferentially uses bromide. [20] The average concentration of bromide in ...
Potassium bromide (K Br) is a salt, widely used as an anticonvulsant and a sedative in the late 19th and early 20th centuries, with over-the-counter use extending to 1975 in the US. Its action is due to the bromide ion (sodium bromide is equally effective). Potassium bromide is used as a veterinary drug, in antiepileptic medication for dogs.
Bromoform was discovered in 1832 by Löwig who distilled a mixture of bromal and potassium hydroxide, as analogous to preparation of chloroform from chloral. [5]Bromoform can be prepared by the haloform reaction using acetone and sodium hypobromite, by the electrolysis of potassium bromide in ethanol, or by treating chloroform with aluminium bromide.
Sodium bromide is widely used for the preparation of other bromides in organic synthesis and other areas. It is a source of the bromide nucleophile to convert alkyl chlorides to more reactive alkyl bromides by the Finkelstein reaction: NaBr + RCl → RBr + NaCl (R = alkyl)
These methods work best when the bromide product is stable to hydrolysis; otherwise, the possibilities include high-temperature oxidative bromination of the element with bromine or hydrogen bromide, high-temperature bromination of a metal oxide or other halide by bromine, a volatile metal bromide, carbon tetrabromide, or an organic bromide.
These may be metal salts containing bromide ion such as potassium bromide, or more covalent bromides of metals or nonmetals such as tantalum(V) bromide or phosphorus tribromide. See also [ edit ]
Bromide ions, as provided by salts like sodium bromide, function as a nucleophiles in the formation of organobromine compounds by displacement. [4] An example of this salt mediated bromide displacement is the use of Copper(II) bromide on ketones: [5] [6] R-CO-CH 2-R' + 2 CuBr 2 → R-CO-CHBr-R' + 2 CuBr + HBr
These methods work best when the bromide product is stable to hydrolysis; otherwise, the possibilities include high-temperature oxidative bromination of the element with bromine or hydrogen bromide, high-temperature bromination of a metal oxide or other halide by bromine, a volatile metal bromide, carbon tetrabromide, or an organic bromide.