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A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Silodosin, sold under the brand name Urief among others, is a medication used for the symptomatic treatment of benign prostatic hyperplasia. [ 4 ] [ 5 ] It acts as an alpha-1 adrenergic receptor antagonist .
An enlarged prostate is common in older men and typically carries symptoms of lower urinary tract problems, which can become bladder problems over time. Tadalafil is typically taken daily for BPH.
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
Sildenafil (marketed as Viagra) was the first PDE5 inhibitor on the market. Originally created as a treatment for high blood pressure in 1989, it was found to have a secondary use as an effective PDE5 inhibitor, enabling men who use it to gain stronger erections after arousal. The FDA approved Viagra on March 27, 1998. [20]
The Best ED Medication for Men: Pros & Cons of Top ED Pills. Over the last 25 years, (ED) medications like Viagra and Cialis have become common fixtures in bedrooms around the world.