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Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...
Dual serotonin and norepinephrine reuptake inhibition resides in different enantiomers for arylthiomethyl morpholine scaffold. [41] Possible drug candidates with dual serotonin and norepinephrine reuptake inhibitory activity have also been derived from piperazine, 3-amino-pyrrolidine and benzylamine templates. [42]
In accordance with the preceding, serotonin 5-HT 2C receptor antagonists like SB-242084 and SB-206553 have been found to increase dopamine levels in the nucleus accumbens. [107] [108] Agomelatine is a potent melatonin MT 1 and MT 2 receptor agonist and weak serotonin 5-HT 2B and 5-HT 2C receptor antagonist that is marketed as an antidepressant ...
Selective serotonin reuptake inhibitors, for example, work to boost serotonin levels, which can help boost mood. A popular prescription is bupropion, ...
Serotonin–norepinephrine reuptake inhibitors (SNRIs) such as venlafaxine (Effexor), its active metabolite desvenlafaxine (Pristiq), and duloxetine (Cymbalta) prevent the reuptake of both serotonin and norepinephrine, however their efficacy appears to be only marginally greater than the SSRIs.
Exercise: Regular physical activity is an effective way to increase serotonin levels. Exercise can be as effective as taking medication for people with moderate depression, in some cases ...