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A High resolution 3D live-cell fluorescence image of a tunneling nanotube (TNT) (white arrow) connecting two primary mesothelial cells. Scale bar: 20 μm. B Depiction of a TNT (black arrow) between two cells with scanning electron microscopy.
Intracellular transport is the movement of vesicles and substances within a cell. Intracellular transport is required for maintaining homeostasis within the cell by responding to physiological signals. [1] Proteins synthesized in the cytosol are distributed to their respective organelles, according to their specific amino acid’s sorting ...
The second method of transport out of the endoplasmic reticulum involves areas called membrane contact sites, where the membranes of the endoplasmic reticulum and other organelles are held closely together, allowing the transfer of lipids and other small molecules. [15] [16] The rough endoplasmic reticulum is key in multiple functions:
Exocytosis is the process by which a large amount of molecules are released; thus it is a form of bulk transport. Exocytosis occurs via secretory portals at the cell plasma membrane called porosomes. Porosomes are permanent cup-shaped lipoprotein structures at the cell plasma membrane, where secretory vesicles transiently dock and fuse to ...
Cell junctions [1] or junctional complexes are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals. [2]
This type of intercellular communication within an organism is commonly referred to as cell signalling. This type of intercellular communication is typified by a small signalling molecule diffusing through the spaces around cells, [5] often relying on a diffusion gradient forming part of the signalling response.
Dynein-mediated transport takes place from the (+) end towards the (-) end of the microtubule. ATP hydrolysis occurs in the globular head domains, which share similarities with the AAA+ (ATPase associated with various cellular activities) protein family. ATP hydrolysis in these domains is coupled to movement along the microtubule via the ...
The method of choice is dependent on physical and chemical properties of the transporting compounds; however, the intercellular route is the most common. Thus, the intercellular lipid barrier has been a subject of investigation to allow for greater understanding of how to develop transportation mechanisms of molecules through the stratum corneum.