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Bipolar disorder has one of the highest rates of suicide amongst psychiatric disorders, as well as high comorbidity rates with alcohol and substance use disorders. [2] Bipolar disorder has a genetic component. [3] This means that the sequence of nucleotides in DNA contains information that can lead to bipolar disorder in individuals ...
Bipolar disorder is associated with elevated basal and dexamethasone elicited cortisol and adrenocorticotropic hormone (ACTH). These abnormalities are particularly prominent in mania, and are inversely associated with antipsychotic use. [97] The incidence of psychiatric symptoms associated with corticosteroids is between 6% and 32%.
Older twin studies suggest that 79 percent to 93 percent of the risk of bipolar disorder is genetic. A more recent twin study identified specific genes associated with bipolar disorder.
The diagnosis of bipolar disorder can be complicated by coexisting psychiatric conditions including obsessive–compulsive disorder, substance-use disorder, eating disorders, attention deficit hyperactivity disorder, social phobia, premenstrual syndrome (including premenstrual dysphoric disorder), or panic disorder.
Is bipolar disorder genetic? A 2021 study by the Psychiatric Genomics Consortium, an international consortium of scientists dedicated to studying the genetic basis of psychiatric disorders, ...
The basic principle behind psychiatric genetics is that genetic polymorphisms (as indicated by linkage to e.g. a single nucleotide polymorphism) are part of the causation of psychiatric disorders. [1] Psychiatric genetics is a somewhat new name for the old question, "Are behavioral and psychological conditions and deviations inherited?".