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A Michael reaction is used as a mechanistic step by many covalent inhibitor drugs. Cancer drugs such as ibrutinib, osimertinib, and rociletinib have an acrylamide functional group as a Michael acceptor. The Michael donor on the drug reacts with a Michael acceptor in the active site of an enzyme. This is a viable cancer treatment because the ...
Some non-English language keyboards have special keys to produce accented modifications of the standard Latin-letter keys. In fact, the standard British keyboard layout includes an accent key on the top-left corner to produce àèìòù, although this is a two step procedure, with the user pressing the accent key, releasing, then pressing the letter key.
Cycle through installed keyboard languages / input methods: Alt+⇧ Shift, Ctrl+⇧ Shift, ⊞ Win+Space, ⊞ Win+⇧ Shift+Space. Alt+⇧ Shift changes between languages while Ctrl+⇧ Shift changes between keyboard layouts of the same language. The latter two display a menu with the currently selected input method highlighted, and debuted in ...
Key stroke lifespan Drop x Invyr Kailh Holy Panda [22] MX Type stem Tactile N/A 67 g 67 g 67 g 1.2 mm 4.0 mm Plate mounting No Yes 80 million Drop Kailh Halo True [23] MX Type stem Tactile N/A 60 g 54 g 100 g 1.9 mm 4.0 mm Plate mounting Yes Yes 80 million Drop Kailh Halo Clear [23] MX Type stem Tactile N/A 65 g 52 g 78 g 1.9 mm 4.0 mm
A typical 105-key computer keyboard, consisting of sections with different types of keys. A computer keyboard consists of alphanumeric or character keys for typing, modifier keys for altering the functions of other keys, [1] navigation keys for moving the text cursor on the screen, function keys and system command keys—such as Esc and Break—for special actions, and often a numeric keypad ...
On Sun Microsystems and Lisp machine keyboards, the Meta key is used as a modifier and for Windows keyboards, there is a Windows key. Compact keyboard layouts often use a Fn key. "Dead keys" allow placement of a diacritic mark, such as an accent, on the following letter (e.g., the Compose key).
In computing, a keyboard shortcut (also hotkey/hot key or key binding) [1] is a software-based assignment of an action to one or more keys on a computer keyboard. Most operating systems and applications come with a default set of keyboard shortcuts , some of which may be modified by the user in the settings .
On these devices, a Fn modifier key is used to combine keys to save room and add non-standard functionality; a common use is merging the row with keys F1- F12 with keys that adjust settings such as display brightness, media volume and playback, and keyboard illumination. Fn Lock toggles the default output of these keys.