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A major cause of female infertility is premature ovarian insufficiency. [54] This insufficiency is a heterogeneous disease that affects about 1% of women who are under the age of 40. [54] Some instances of female infertility are caused by DNA repair dysregulation during meiosis. [54]
Male infertility is responsible for 20–30% of infertility cases, while 20–35% are due to female infertility, and 25–40% are due to combined problems in both partners. [29] [5] In 10–20% of cases, no cause is found. [5] The most common cause of female infertility are ovulation problems, usually manifested by scanty or absent menstrual ...
Approximately 20% of female infertility can be attributed to tubal causes. [1] Distal tubal obstruction (affecting the distal tubal opening (towards the ovary)) is typically associated with hydrosalpinx formation and often caused by Chlamydia trachomatis. [1] Pelvic adhesions may be associated with such an infection.
Women in which the presenting symptom is infertility often have diagnoses delayed beyond the average window of 25–29 years of age. [ 6 ] The gold standard for diagnosing endometriosis is a diagnostic laparoscopy , a minimally invasive procedure that involves a camera entering the abdominals through a small incision to examine the abdominal ...
Tubal factors cause 25-30% of infertility cases. [1] Tubal factor is one complication of chlamydia trachomatis infection in women. [2] Sexually transmitted chlamydia and genital mycoplasma infections are preventable causes of infertility and negative pregnancy outcomes. When the infections progress and ascend, they can result in TFI.
In unexplained infertility abnormalities are likely to be present but not detected by current methods. Possible problems could be that the egg is not released at the optimum time for fertilization, that it may not enter the fallopian tube, sperm may not be able to reach the egg, fertilization may fail to occur, transport of the zygote may be disturbed, or implantation fails.
Chronic anovulation is a common cause of infertility. In addition to the alteration of menstrual periods and infertility, chronic anovulation can cause or exacerbate other long-term problems, such as hyperandrogenism or osteopenia. It plays a central role in the multiple imbalances and dysfunctions of polycystic ovary syndrome.
Not all women with PCOS have difficulty becoming pregnant. For those who do, anovulation is a common cause. The mechanism of this anovulation is uncertain, but there is evidence of arrested antral follicle development, which, in turn, may be caused by abnormal interaction of insulin and luteinizing hormone (LH) on granulosa cells.