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2. Cialis Side Effects: What to Expect (& How to Avoid Them) - AOL

   www.aol.com/cialis-side-effects-expect-avoid...

   However, in clinical trials, high blood pressure was reported in just one percent of patients taking 2.5-milligram tadalafil and three percent of patients taking the 5-milligram dose.

3. Tadalafil: Your Ultimate Guide to Dosages, Side Effects & More

   www.aol.com/tadalafil-ultimate-guide-dosages...

   Tadalafil is available in several dosages, from a minimum dosage of 2.5mg (milligrams) all the way up to a 20mg per tablet, the maximum dose of tadalafil in 24 hours. Tadalafil 10mg: Typical ...

4. Got Headaches from Viagra or Cialis? Here's Why & How to Treat It

   www.aol.com/got-headaches-viagra-cialis-heres...

   Sildenafil, tadalafil and other treatments for ED all belong to a class of medications called phosphodiesterase type 5 or PDE5 inhibitors, which dilate the blood vessels that supply blood to the ...

5. Tadalafil - Wikipedia

   en.wikipedia.org/wiki/Tadalafil

   Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. [ 5 ] [ 6 ] [ 8 ] It is taken by mouth . [ 8 ]

6. Dental anesthesia - Wikipedia

   en.wikipedia.org/wiki/Dental_anesthesia

   Epinephrine in high doses is harmful to a pregnant woman in that it affects uterine blood flow. However its use in low dose with local anesthetic administration is warranted. The epinephrine causes vasoconstriction which in turn reduces systemic distribution of the anesthetic as well as prolongs its action in addition to decreasing bleeding at ...

7. Therapeutic index - Wikipedia

   en.wikipedia.org/wiki/Therapeutic_index

   For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.