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HCN channels are sometimes referred to as pacemaker channels because they help to generate rhythmic activity within groups of heart and brain cells. HCN channels are activated by membrane hyperpolarization, are permeable to Na + and K +, and are constitutively open at voltages near the resting membrane potential. [2]
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been identified as channels that mediate hyperpolarization. They were initially discovered in pacemaker cells of the heart. [ 7 ] These channels are controlled by cAMP, and activated by a hyperpolarized membrane.
15165 Ensembl ENSG00000164588 ENSMUSG00000021730 UniProt O60741 O88704 RefSeq (mRNA) NM_021072 NM_010408 RefSeq (protein) NP_066550 NP_034538 Location (UCSC) Chr 5: 45.25 – 45.7 Mb Chr 13: 117.74 – 118.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 ...
The molecular determinants of the pacemaker current belong to the HCN channel (hyperpolarization-activated cyclic nucleotide–gated channel), of which 4 isoforms (HCN1 to HCN4) are known. Based on their sequence, HCN channels are classified as members of the superfamily of voltage-gated K + (Kv) and CNG channels. [3] [8]
Hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) are located mainly in pacemaker cells, these channels become active at very negative membrane potentials and allow for the passage of both Na + and K + into the cell (which is a movement known as a funny current, I f). These poorly selective, cation (positively charged ...
These channels, formally called hyperpolarization-activated cyclic nucleotide–gated channels (HCN channels), are also termed "pacemaker channels" because of this critical function. As their name implies, they are open during conditions of hyperpolarization and closed during depolarization.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. [5] [6] [7] [8]There are four HCN channels.
15166 Ensembl ENSG00000099822 ENSMUSG00000020331 UniProt Q9UL51 O88703 RefSeq (mRNA) NM_001194 NM_008226 RefSeq (protein) NP_001185 NP_032252 Location (UCSC) Chr 19: 0.59 – 0.62 Mb Chr 10: 79.55 – 79.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the ...