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Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase . It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses ( vaccinia [ 1 ] [ 2 ] and herpesviruses ) and an apoptosis inducer in HeLa cells.
Aphidicolan-16β-ol synthase (EC 4.2.3.42, PbACS) is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase (aphidicolan-16β-ol-forming). [1] [2] This enzyme catalyses the following chemical reaction
Aphidicolin is a mycotoxin originally known to be produced by the fungus, Cephalosporium aphidicola. This antiviral compound was isolated in mycelium culture filtrate of N. sphaerica. [11] Epoxyexserophilone is a metabolite similar to the phytotoxin, exserohilone. Fermentation of N. sphaerica led to the production of epoxyexserophilone.
A synthesis of Aphidicolin use methodology around the vinylcyclopropane rearrangement developed in their own laboratory . [40] A key step converts a late stage siloxyvinylcyclopropane into a cyclopentene that contained the [6-6-5]-fused carbon skeleton found within the natural product.
In some experiments, a researcher may want to control and synchronize the time when a group of cells progress to the next phase of the cell cycle. [5] The cells can be induced to arrest as they arrive (at different time points) at a certain phase, so that when the arrest is lifted (for instance, rescuing cell cycle progression by introducing another chemical) all the cells resume cell cycle ...
Lise Meitner (1878–1968) was an Austrian-Swedish nuclear physicist who was instrumental in the discovery of nuclear fission and protactinium.In 1905, she became the second woman from the University of Vienna to earn a doctorate in physics.
This page was last edited on 12 December 2017, at 16:04 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
[1] The replication factor C, or RFC, is a five-subunit [2] protein complex that is required for DNA replication. The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 in Saccharomyces cerevisiae.