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2. Antimigraine drug - Wikipedia

   en.wikipedia.org/wiki/Antimigraine_drug

   The triptan drug class includes 1st generation sumatriptan (which has poor bioavailability), and second generation zolmitriptan. [2] Due to their safety, efficacy and selectivity, triptans are considered first line agents for abortion of migraines. [2] These medications are selective 5-HT 1B/1D receptor agonists with some activity at 5-HT 1F.

3. Discovery and development of triptans - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   The selection of anti-migraine drug for patients depends on their symptoms. The first selective 5-HT 1B/1D agonist, sumatriptan, was first synthesized as a subcutaneous injection, then as an oral tablets and more recently as a nasal spray, it is also available in some countries as suppositories. The subcutaneous injection is the fastest way to ...

4. Triptan - Wikipedia

   en.wikipedia.org/wiki/Triptan

   The drugs of this class act as agonists for serotonin 5-HT 1B and 5-HT 1D receptors at blood vessels and nerve endings in the brain. The first clinically available triptan was sumatriptan, which has been marketed since 1991. Triptans have largely replaced ergotamines, an older class of medications used to relieve migraine and cluster headaches. [3]

5. FDA approves first drug to prevent migraines - AOL

   www.aol.com/news/2018-05-18-fda-approves-first...

   The Food and Drug Administration approved on Thursday the first drug designed to prevent migraines. A once-monthly, self-injection, Aimovig is the first in a new class of long-acting drugs that is ...

6. Sumatriptan - Wikipedia

   en.wikipedia.org/wiki/Sumatriptan

   The most common side effects [14] reported by at least 2% of patients in controlled trials of sumatriptan (25-, 50-, and 100-mg tablets) for migraine are atypical sensations (paresthesias and warm/cold sensations) reported by 4% in the placebo group and 5–6% in the sumatriptan groups, pain and other pressure sensations (including chest pain ...

7. Why it’s so important to get help for migraine attacks - AOL

   www.aol.com/why-important-help-migraine-attacks...

   Given as pills, shots, or nasal sprays, these medications treat a migraine attack by blocking pain pathways to the brain. They include prescription drugs such as sumatriptan (Imitrex, Tosymra) and ...