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MCHC can be normal even when hemoglobin production is decreased (such as in iron deficiency) due to a calculation artifact. MCHC can be elevated ("hyperchromic") in hereditary spherocytosis, sickle cell disease and homozygous hemoglobin C disease, depending upon the hemocytometer. [4] [5] MCHC can be elevated in some megaloblastic anemias. MCHC ...
As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of vitamin B 6, folic acid (vitamin B 9), and vitamin B 12 can lead to high homocysteine levels. [2] Other possible causes of hyperhomocysteinemia include genetics, excessive methionine intake, and other diseases.
HbC can combine with other abnormal hemoglobins and cause serious hemoglobinopathies. Individuals with sickle cell–hemoglobin C (HbSC), have inherited the gene for sickle cell disease (HbS) from one parent and the gene for hemoglobin C disease (HbC) from the other parent. Since HbC does not polymerize as readily as HbS, there is less sickling ...
Anabolic steroid use – people whose testosterone levels are high, including athletes who abuse steroids, people on testosterone replacement for hypogonadism or transgender hormone replacement therapy. [18] Blood doping – Athletes who take erythropoietin-stimulating agents or receive blood transfusions to increase their red blood cell mass. [29]
Sometimes sports injuries can be so severe that they lead to death. In 2010 48 youths died from sports injuries. [48] The leading causes of death in youth sports are sudden cardiac arrest, concussion, heat illness and external sickling. [49] Cardiac-related deaths are usually due to an undiagnosed cardiovascular disorder. [50]
The women with the highest levels of IgM anti-PC had a 73% lower risk of CVD than those in the group with the lowest levels. The reduction was most evident in the risk of ischemic heart disease ...
Macrocytic anemias have several causes but with the implementation of folic acid fortification in North America, folate deficiency has become a rare cause of megaloblastic macrocytic anemia in that part of the world. [1] In this region, Vitamin B 12 deficiency is a far more common cause of megaloblastic macrocytic anemia. [1]
It happens over time and can be due to the effects of aging, overuse of a joint, or injury. Then there’s inflammatory arthritis. This category of arthritis is the result of an inflammatory ...