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Urine sodium is a measurement of the concentration of sodium in the urine. It is a test ordered to distinguish between forms of renal failure and to classify the severity of hyponatremia. [1] The urine sodium is expressed as a concentration (such as millimoles per liter).
The urine concentrations of sodium, chlorine and potassium may be used to investigate conditions such as abnormal blood electrolyte levels, acute kidney injury, metabolic alkalosis and hypovolemia. [ 1 ] [ 2 ] [ 3 ] Other electrolytes that can be measured in urine are calcium , phosphorus and magnesium .
The fractional excretion of sodium (FE Na) is the percentage of the sodium filtered by the kidney which is excreted in the urine.It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary sodium concentration alone, as urinary sodium concentrations can vary with water reabsorption.
Blood tests are also used to assess kidney function. These include tests that are intended to directly measure the function of the kidneys, as well as tests that assess the function of the kidneys by looking for evidence of problems associated with abnormal function. One of the measures of kidney function is the glomerular filtration rate (GFR).
Hyponatremia or hyponatraemia is a low concentration of sodium in the blood. [4] It is generally defined as a sodium concentration of less than 135 mmol/L (135 mEq/L), with severe hyponatremia being below 120 mEq/L. [3] [8] Symptoms can be absent, mild or severe.
Hypernatremia, also spelled hypernatraemia, is a high concentration of sodium in the blood. [3] Early symptoms may include a strong feeling of thirst, weakness, nausea, and loss of appetite. [1]
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The term "normal saline" itself appears to have little historical basis, except for studies done in 1882–83 by Dutch physiologist Hartog Jacob Hamburger; these in vitro studies of red cell lysis suggested incorrectly that 0.9% was the concentration of salt in human blood (rather than 0.6%, the true concentration). [35]