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[4] [5] [12] [13] It is available as an implant placed under the skin of the upper arm under the brand names Nexplanon and Implanon. It is a progestin that is also used in combination with ethinylestradiol , an estrogen , as a vaginal ring under the brand names NuvaRing and Circlet . [ 14 ]
Men experience sexual dysfunction at testosterone levels of below 300 ng/dL, with men that have levels of testosterone of approximately 200 ng/dL often experiencing such problems. [28] Complete loss of testicular testosterone production resulting in testosterone levels within the castrate range (95% decrease, to 15 ng/dL on average) with ...
As such, they are only generally associated with such effects in women and often only at high doses. In men, due to their concomitant progestogenic activity and by extension antigonadotropic effects, these progestins can have potent functional antiandrogenic effects via suppression of testosterone production and levels.
High-dose estrogen therapy works by suppressing testosterone levels, similarly to high-dose progestogen therapy and gonadotropin-releasing hormone (GnRH) modulator therapy. [45] Lower dosages of estrogens have also been used in combination with high-dose progestogen therapy in the treatment of sexual deviance in men. [ 45 ]
[85] [62] However, in contrast, the effects of the elevated estrogen levels remain unopposed by bicalutamide, and this is importantly involved in the feminizing side effects (e.g., gynecomastia) of the drug in men. [106] Testosterone levels decline with age in men and younger men have higher testosterone levels on average than older men. [107]
Testosterone levels very with age, according to the Cleveland Clinic, and start to drop around age 30 or 40. Women turn to weight loss drugs in menopause: What to know about the benefits and risks
Plus, many medications bring side effects for some people, Dr. Gittens says. He suggests clinicians get a base testosterone level for men taking GLP-1s and discuss their potential effects on T levels.
A dosage of two to six 100 μg/day transdermal estradiol patches can achieve mean levels of estradiol in the area of 200 to 400 pg/mL and can be used as a form of high-dose estrogen therapy, for instance to suppress testosterone levels in the treatment of prostate cancer in men and in feminizing hormone therapy for transgender women.
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