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Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [1] It is usually found in body folds, [ 2 ] such as the posterior and lateral folds of the neck , the armpits , groin , navel , forehead and other areas.
People with these conditions are generally of normal intelligence. [2] Several features distinguish Crouzonodermoskeletal syndrome from Crouzon syndrome. People with Crouzonodermoskeletal syndrome have acanthosis nigricans, a skin condition characterized by thick, dark, velvety skin in body folds and creases, including the neck and underarms.
Acanthosis nigricans is a skin condition in which areas of the skin is of a dark and velvety discoloration, often seen in the body folds and creases such as the armpits, groin, and neck. [6] Within those affected by SADDAN, acanthosis nigricans develops early on, usually in infancy or early childhood. [4]
Malignant acanthosis nigricans may also become evident, many times with the sudden eruption of multiple seborrheic keratoses, known as the sign of Leser-Trélat. [ 9 ] [ 10 ] [ 11 ] Florid cutaneous papillomatosis mandates a search for an underlying malignancy, recognizing that it may be seen in patients with multiple visceral carcinomas.
Obesity is the chief symptom of HAIR-AN. [4] In the majority of young women affected by HAIR-AN, hyperandrogenism leads to oily skin, acne, hirsutism, menstrual irregularities and, in some cases, androgenic alopecia, clitoromegaly, changes in muscle mass and deepening of the voice.
Endocrine-related cutaneous conditions often present with cutaneous findings as the skin interacts with the endocrine system in many ways. ... Acanthosis nigricans;
Lelis syndrome is a genetic disorder, a rare condition with dermatological and dental findings [1] characterized by the association of ectodermal dysplasia (hypotrichosis and hypohidrosis) with acanthosis nigricans.
Cushing's syndrome Acanthosis nigricans associated with obesity, insulin-resistant states, and endocrinopathy; Excess ovarian androgen release syndrome (ovarian SAHA syndrome) Familial acanthosis nigricans (acanthosis nigricans type II) Growth hormone deficiency; Hyperandrogenism–insulin resistance–acanthosis nigricans syndrome (HAIR-AN ...