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The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the membrane). The B-cell ...
B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. [1] BCRs allow the B cell to bind to a foreign antigen, against which it will initiate an antibody response. [1] B cell receptors are extremely specific, with all BCRs on a B cell recognizing the same ...
BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. [8] BAFF is the natural ligand of three nonconventional tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of ...
CD79 (Cluster of Differentiation 79) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (also known as Igα and Igβ); these form a heterodimer on the surface of a B cell stabilized by ...
BLNK is essential for normal B-cell development as part of the B cell receptor signaling pathway. [supplied by OMIM] [10] [23] [24] Evidence also suggests that BLNK may have tumor suppressive activity through its interaction with Bruton's tyrosine kinase (Btk) [25] [26] and regulation of the pre-B cell checkpoint. [14] [27]
The mouse CD79A gene, then called mb-1, was cloned in the late 1980s, [8] followed by the discovery of human CD79A in the early 1990s. [9] [10] It is a short gene, 4.3 kb in length, with 5 exons encoding for 2 splice variants resulting in 2 isoforms.
After acquiring these mutations, the receptors on the surface of the B cells (B cell receptors) are tested within the germinal center for their affinity to the current antigen. [9] B cell clones with mutations that have increased the affinity of their surface receptors receive survival signals via interactions with their cognate T FH cells.
The MZ B cells within this region typically express low-affinity polyreactive B-cell receptors (BCR), high levels of IgM, Toll-like receptors (TLRs), CD21, CD1, CD9, CD27 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. [2] [3]