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The origins of some immortal cell lines – for example, HeLa human cells – are from naturally occurring cancers. HeLa, the first immortal human cell line on record to be successfully isolated and proliferated by a laboratory, was taken from Henrietta Lacks in 1951 at Johns Hopkins Hospital in Baltimore, Maryland. [1]
A 2010 episode of Law & Order, "Immortal", was heavily based on the story of Henrietta Lacks and the HeLa cell line, using the fictional "NaRo" cells as a stand-in. [68] The story of how the HeLa cell line came to be was also the subject of a 2010 episode of the podcast Radiolab. [69]
This is an accepted version of this page This is the latest accepted revision, reviewed on 19 January 2025. African-American woman (1920–1951), source of HeLa immortal cell line "Lacks" redirects here. For other uses, see Lack. Henrietta Lacks Lacks c. 1945–1951. Born Loretta Pleasant (1920-08-01) August 1, 1920 Roanoke, Virginia, U.S. Died October 4, 1951 (1951-10-04) (aged 31) Baltimore ...
Embryonic stem cells and germ cells have also been described as immortal. [8] [9] Immortal cell lines of cancer cells can be created by induction of oncogenes or loss of tumor suppressor genes. One way to induce immortality is through viral-mediated induction of the large T-antigen, [10] commonly introduced through simian virus 40 (SV-40). [11]
The book is about Henrietta Lacks and the immortal cell line, known as HeLa, that came from Lacks's cervical cancer cells in 1951. Skloot became interested in Lacks after a biology teacher referenced her but knew little about her. Skloot began conducting extensive research on her and worked with Lacks' family to create the book.
Immortalized cell lines can be generated from cells isolated from tumors, or mutations can be introduced to make the cells immortal. [1] A stem cell line is also distinct from primary cells. Primary cells are cells that have been isolated and then used immediately.
The I 9.2 and I 2.1 cell lines. The I 2.1 cell line is functionally defective for FADD and the I 9.2 cell line is functionally defective for caspase-8, both defective molecules being essential to apoptosis or necroptosis of cells. The D1.1 cell line does not express the CD4 molecule, an important co-receptor in the activation pathway of helper ...
Hep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old Caucasian male from Argentina with a well-differentiated hepatocellular carcinoma. [1] These cells are epithelial in morphology, have a modal chromosome number of 55, and are not tumorigenic in nude mice. [2]