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Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
Otto Warburg postulated this change in metabolism is the fundamental cause of cancer, [8] a claim now known as the Warburg hypothesis. Today, mutations in oncogenes and tumor suppressor genes are thought to be responsible for malignant transformation , and the Warburg effect is considered to be a result of these mutations rather than a cause.
Warburg investigated the metabolism of tumors and the respiration of cells, particularly cancer cells, and in 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme". [1] In particular, he discovered that animal tumors produce large quantities of lactic acid. [6]
In the absence of hypoxic conditions (i.e. physiological levels of oxygen), cancer cells preferentially convert glucose to lactate, according to Otto H. Warburg, who believed that aerobic glycolysis was the key metabolic change in cancer cell malignancy. The "Warburg effect" was later coined to describe this metabolic shift. [6]
The Warburg effect, named for Otto Heinrich Warburg, may refer to: Warburg effect (embryology) Warburg effect inversion; Warburg effect (oncology)
A few months later, Bloodgood asked Geschickter to come back and help him at the new Garvan Cancer Research Laboratory. Geschickter agreed, and before starting work made a tour of pathology laboratories in Europe, including the biochemistry unit run by Otto Heinrich Warburg in Berlin. His main interest after this was in cancer research and ...